Tehran's influence has grown since it began supporting President Bashar al-Assad in the civil war that started in 2011.
The attacks on an IRGC operational headquarters destroyed the building, local media reported.
The last Israeli airstrikes to hit Syria were reported about two weeks ago, when the IDF struck a Syrian air defense battery after a Syrian air defense missile exploded mid-air over southern Israel.
The negotiations began in February and March of the same year, with representatives from both Israel and Syria presenting their initial plans to the then-US Secretary of State.
Several missiles were reportedly intercepted by Syrian air defense systems.
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