PhenQ vs Zmyra vs Ozempic: Best Weight Loss Options Reviewed (OTC Alternatives or Semaglutide)

  (photo credit: PR)
(photo credit: PR)

PhenQ, Zmyra, and Ozempic are three popular weight loss products available in 2024.

All three weight loss products, however, work in very different ways.

Ozempic is an FDA-approved, prescription medication built to improve blood sugar control. The drug is frequently prescribed off-label as a weight loss aid.

PhenQ and Zmyra, meanwhile, are weight loss supplements – not drugs. They’re available over-the-counter (without a prescription) and contain a blend of natural ingredients – not synthetics of pharmaceuticals.

Keep reading to learn about the differences, similarities, pros, and cons of PhenQ vs. Zmyra vs. Ozempic.

PhenQ & Zmyra Are Supplements, While Ozempic is a Drug

Ozempic has been extensively studied by researchers worldwide and verified to work in clinical trials. Those clinical trials motivated the United States Food and Drug Administration (FDA) and other governing bodies to approve Ozempic to treat high blood sugar. The FDA approved Ozempic for weight management in 2021.

Although Ozempic is primarily designed as a blood sugar medication for diabetics, it’s frequently prescribed “off-label” for other purposes, like for weight loss in people who may or may not have diabetes.

PhenQ & Zmyra are not weight loss drugs; they’re weight loss supplements – just like protein powders, diet pills, and caffeine pills are weight loss supplements. Anyone can buy these products over the counter without a prescription, and they’re widely available online or over the Internet. The FDA hasn’t approved PhenQ, Zmyra, or other weight loss supplements.

PhenQ vs. Zmyra vs. Ozempic: How They Work

PhenQ, Zmyra, and Ozempic are all known for helping people lose weight. However, they promote weight loss in different ways.

Ozempic is a GLP-1 Receptor Agonist

Ozempic, for example, is a glucagon-like peptide-1 receptor agonist. It interacts with a specific receptor in your body linked to fullness and appetite control. By interacting with this receptor, Ozempic can slow the transit of food from your stomach into your digestive tract, helping you stay fuller for longer after a meal (and reducing your post-meal blood sugar spike. Because Ozempic helps control blood sugar, it can also help with appetite control: blood sugar fluctuations can cause you to crave sweets and carbs.


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  • Increases fullness and suppresses appetite
  • Helps control blood sugar to reduce cravings for carbs and sweets
  • Mimics a hormone linked to appetite, fullness, and hunger

Click here to learn more about Ozempic >>>

PhenQ Uses Metabolism Boosters to Increase Calorie Burning

PhenQ doesn’t contain the controlled weight loss drug, phentermine. The FDA banned phentermine decades ago for its connection to heart problems. However, PhenQ remains popular today for its purported ability to burn fat in multiple ways. PhenQ contains caffeine, one of the world’s most proven fat burners. It also contains an amino acid-rich substance called nopal cactus, which could boost energy and weight loss. It also contains capsaicin (Capsimax powder), niacin, chromium, and L-carnitine.

Together, these mechanisms could support your body’s natural weight loss processes. According to the makers of PhenQ, the supplements work in five ways to promote weight loss:

  • Burn fat
  • Stop fat production
  • Suppress appetite
  • Boost energy
  • Improve mood

Click here to learn more about PhenQ >>>

Zmyra Uses a Four-Stage Fat Burning System & Fiber for Weight Loss

Zmyra uses a proprietary, four-stage fat-burning system to help anyone lose weight. The goal of the supplement is to promote weight loss with minimal diet or exercise required. To do that, Zmyra uses a formula similar to PhenQ’s: like PhenQ, Zmyra contains fiber and caffeine to promote metabolism and appetite control. However, it also contains alpha lipoic acid and other natural antioxidants. These ingredients could help trigger your body’s natural fat-burning processes. The largest ingredient, however, is fiber, which physically takes up space in your digestive tract to promote fat burning.

Because of these effects, Zmyra claims it’s “not like most diet pills” and “works with your body” instead of against it. By taking Zmyra daily, you could purportedly lose weight via mechanisms like:

  • Control appetite and reduce cravings
  • Boost energy and metabolism
  • Four-stage fat-burning formula

Click here to learn more about Zmyra >>>

PhenQ vs. Zmyra vs. Ozempic: Prescription vs. Over-the-Counter

One of the biggest differences between PhenQ, Zmyra, and Ozempic is in availability and ease of purchase. You can’t simply walk into a store and purchase Ozempic off the shelf. Instead, you need to schedule a consultation with a doctor. PhenQ and Zmyra, meanwhile, are as easy to buy as protein powders or caffeine pills.

Ozempic is Prescription-Only

Whether you buy name-brand Ozempic or compounded Semaglutide, you must consult a doctor to receive Ozempic legally. It’s not over-the-counter; you can’t simply walk into a pharmacy and buy it. You can, however, buy it from the comfort of your home using online pharmacies, which schedule a virtual consultation.

Generally, doctors prescribe Ozempic if you have a BMI over 30 or a BMI over 27 and a related medical condition, assuming you have no other medical conditions or medications that could interact with Ozempic.

Zmyra & PhenQ Are Over-the-Counter Supplements

Zmyra and PhenQ are supplements; anyone can buy them without a prescription. Whether you want to buy one bottle of Zmyra or 100 bottles of PhenQ, you can legally order as many supplements online without a doctor’s consultation, virtual appointment, or any paperwork.

Instead, all you need to buy Zmyra and PhenQ is a credit card and a shipping address.

PhenQ vs. Zmyra vs. Ozempic: Active Ingredients

PhenQ, Zmyra, and Ozempic contain different ingredients to target weight loss in different ways.

Ozempic contains Semaglutide, a synthetic peptide created in a lab. It’s chemically similar to a hormone created by your body (the GLP-1 hormone). However, it’s modified in a lab to increase the safety and efficacy of the drug for weight loss.

PhenQ’s largest ingredients include calcium (230mg), L-carnitine (150mg), and caffeine. The supplement also contains smaller doses of nopal cactus fiber, alpha-Lacys Reset, and capsaicin, among other plant-based, natural ingredients.

Zmyra contains a large dose of glucomannan (250mg), a fiber extract that takes up greater physical space in your digestive tract, helping you stay fuller for longer. It also contains L-carnitine (200mg), alpha lipoic acid (100mg), caffeine (100mg), and cayenne (100mg).

PhenQ vs. Zmyra vs. Ozempic: Scientific Evidence

The biggest difference between PhenQ, Zmyra, and Ozempic is in the scientific evidence backing them.

As supplements, PhenQ and Zmyra have limited FDA oversight. Understandably, the Food and Drug Administration oversees foods and drugs but provides limited direct oversight of supplements. The FDA doesn’t verify supplements work or contain their listed ingredients, for example.

As a drug, Ozempic faces far greater FDA scrutiny. Drugs must pass rigorous safety and efficacy tests before being approved. The FDA approved Ozempic as a blood sugar drug for diabetics after years of trials.

Here’s how the scientific evidence differs between PhenQ, Zmyra, and Ozempic:

A Two-Year Study with 2,000+ Participants backs Ozempic

In 2022, researchers published a landmark study showing once-weekly Semaglutide, at a dose of 2.4mg, could lead to significant weight loss when combined with a healthy diet and exercise program.

Here’s how the Ozempic clinical trial worked:

Participants gathered a group of 1,961 adults with a BMI of 30 or greater (or 27 or greater with a weight-related medical condition). None of these adults had diabetes.

Some adults took 2.4mg of Semaglutide (the active pharmaceutical ingredient in Ozempic) once weekly. Others took a placebo.

All adults in the trial also engaged in lifestyle intervention – including diet and exercise changes.

After 68 weeks of following the program, researchers found that those in the placebo group had lost 2.4% of their body weight, while those in the Ozempic group had lost 14.9%.

Other Ozempic studies have indicated similar results. Instead of summarizing each study, we recommend the Clinical Review Report on Ozempic published by the National Library of Medicine. That report reviewed multiple trials involving thousands of patients, consistently showing Ozempic was safe and effective for promoting weight loss and blood sugar control.

Zmyra and PhenQ Aren’t Backed by Any Specific Clinical Trials

Most supplement companies don’t conduct clinical trials. Clinical trials cost a lot, and they don’t always deliver the expected results. That’s why, unsurprisingly, neither Zmyra or PhenQ are backed by specific clinical trials verifying they work for weight loss.

However, both Zmyra and PhenQ contain ingredients backed by clinical trials – including well-known weight loss ingredients like caffeine, capsaicin, and alpha lipoic acid. These ingredients have been shown to work in clinical trials. Although PhenQ and Zmyra, as a whole, haven’t been verified to work, the individual ingredients within the supplement have been shown to work.

PhenQ, for example, touts alpha-Lacys Reset, a special combination of alpha lipoic acid and L-cysteine found in the supplement. Nutraceutical International Group developed that ingredient specifically to help with inflammation, recovery, and weight management. That organization has studied alpha-Lacys Rest to verify that it works as advertised. One study, for example, found that alpha-Lacys Reset led to a 7.24% drop in body fat, a 3.44% drop in body weight, and a 3.80% increase in muscle mass.

PhenQ vs. Zmyra vs. Ozempic: FDA Approval

As mentioned above, the FDA is known for governing foods and drugs – not supplements. That’s why, unsurprisingly, the FDA has approved Ozempic but has not approved PhenQ, Zmyra, or other weight loss supplements:

The FDA approved Ozempic for weight management in 202. It was the first weight management drug approved by the FDA since 2014. The FDA praised Ozempic for giving obese or overweight adults “a beneficial new treatment option to incorporate into a weight management program,” finding it mimics a hormone linked to appetite control.

Neither PhenQ, Zmyra, or any weight loss supplement have been approved by the FDA. The FDA periodically issues warnings to supplement companies – say, if they’re caught being advertised as a cure, treatment, or preventative measure for a disease or if they’re found to be unsafe. As far as the internet goes, the FDA has never tested, researched, or approved or disproved PhenQ / Zmyra in any way, shape, or form.

PhenQ vs. Zmyra vs. Ozempic: Pricing

PhenQ, Zmyra, and Ozempic have different price points.

  • Ozempic costs $1,000 to $2,000 monthly, depending on your location, dosage, and treatment plan.
  • PhenQ and Zmyra are $49 to $79 per bottle, depending on the number of bottles you order.

PhenQ vs Zmyra vs Ozempic: Availability & Ease of Purchase

It’s not just about pricing. Ozempic, PhenQ, and Zmyra also differ in terms of the ease of purchase:

You can easily buy PhenQ and Zmyra online through their official website and select online retailers, for example.

You can also easily buy Ozempic online or offline, although you may need to schedule a virtual consultation with an online pharmacy and an affiliated physician. Some providers face Ozempic shortages or other issues, while PhenQ and Zmyra rarely sell out.

PhenQ vs. Zmyra vs. Ozempic: Insurance Coverage

Medical insurance in the United States will rarely cover supplements. Many medical plans do, however, cover Ozempic.

Here’s how insurance coverage varies between the three popular weight loss formulas:

Medical insurance may cover Ozempic. Many healthcare insurance companies reduce the cost of Ozempic to $25 to $50 per month – or nothing at all. An insurance company may cover Ozempic for one to two years or require you to follow a doctor-approved treatment plan before covering the cost of the medication.

Medical insurance will not cover PhenQ or Zmyra. They’re supplements, and medical insurance is designed to cover doctor-prescribed drugs – not weight loss supplements.

Covering PhenQ and Zmyra through a workplace benefits package may be possible. Some workplaces provide generous spending for health and wellness, for example, on gym memberships and supplements. If your workplace has a health and wellness benefits package, you could buy PhenQ or Zmyra for free or at a discount.

PhenQ vs. Zmyra vs. Ozempic: Advertised Weight Loss Claims

PhenQ, Zmyra, and Ozempic are all known for their ability to help with weight loss. However, the manufacturers of the three ingredients make different weight loss claims.

Generally, Ozempic is advertised as a way to lose 15% to 20% of your body weight over a one to two year period when combined with a healthy diet and exercise program. It’s not advertised as a “shortcut” to weight loss, and it’s not advertised to work if you’re not eating right or exercising.

PhenQ and Zmyra aren’t advertised as rapid, overnight cures for obesity either. Instead, they’re advertised as a way to complement a healthy, balanced diet and exercise routine to promote weight loss results. However, both official websites are filled with testimonials from customers who appear to have rapidly transformed their bodies by taking the supplements, as evidenced by before-and-after photos.

PhenQ vs. Zmyra vs. Ozempic: Natural vs. Synthetic Ingredients

Some people like only to put natural ingredients in their bodies. Zmyra and PhenQ contain natural ingredients, such as plant extracts and vitamins. Ozempic, meanwhile, uses a synthetic compound called Semaglutide as its active ingredient.

Zmyra and PhenQ contain natural, primarily plant-based ingredients like caffeine, capsaicin, and alpha lipoic acid to promote fat burning. You’ll find nopal cactus, for example, and natural sources of fiber.

Ozempic, meanwhile, is a synthetic peptide similar to a hormone your body produces, glucagon-like peptide-1. Chemically, it’s similar to the human form of GLP-1. However, it’s modified with a side chain: a lab creates the peptide, then makes multiple substitutions, replacing alanine and lysine with 2-aminoisobutyric acid and arginine to increase efficacy. Semaglutide isn’t found in the natural world; it’s a drug manufactured in a lab specifically for weight loss.

PhenQ vs. Zmyra vs. Ozempic: Side Effects

PhenQ, Zmyra, and most weight loss supplements aren’t expected to cause significant side effects when healthy adults take normal doses. Ozempic, meanwhile, is associated with side effects.

PhenQ and Zmyra Contain Generally Recognized As Safe (GRAS) Ingredients Not Linked to Significant Side Effects

PhenQ and Zmyra, like all supplements legally sold in the United States, contain ingredients that are Generally Recognized As Safe (GRAS). They appear on the FDA’s list of ingredients generally considered safe for healthy adults to take in normal doses. GRAS ingredients include canola oil, vinegar, and spices like salt or black pepper. Although the FDA hasn’t approved PhenQ and Zmyra, the ingredients within the supplements are Generally Recognised As Safe. The FDA approved caffeine as a GRAS substance in 1977, for example.

Ozempic is Linked to Side Effects in Some Users

Ozempic, meanwhile, is associated with side effects. Most people don’t experience significant side effects while taking Ozempic, although many do experience mild to severe side effects.

The most common side effects of Ozempic, according to the manufacturer, may include:

  • Nausea
  • Diarrhea
  • Stomach / abdominal pain
  • Vomiting
  • Constipation

Some people also experience “Ozempic face”, headaches, fatigue, hair loss, injection site reactions, and other issues after taking Ozempic. As WebMD reports, some reports have linked thyroid cancer, angioedema, and other serious medical conditions to Ozempic in rare cases.

PhenQ vs. Zmyra vs. Ozempic: Refund Policy

Generally, you can’t receive a refund on drugs like Ozempic. You can stop taking Ozempic and cancel your prescription to avoid future charges. However, most compounded Semaglutide or Ozempic sellers do not provide a refund.

PhenQ and Zmyra, meanwhile, are backed by a 30 to 60-day money-back guarantee:

  • You have 60 days to request a refund on PhenQ
  • You have 30 days to request a refund on Zmyra

PhenQ vs. Zmyra vs. Ozempic: Company Headquarters

Ozempic, Zmyra, and PhenQ are made in different parts of the world:

Novo Nordisk, a Danish multinational pharmaceutical company, makes Ozempic. The company has affiliates or offices in five countries and production facilities in nine countries. When you buy an Ozempic, it can be made in any of these production facilities.

PhenQ, meanwhile, is made by a Glasgow, Scotland-based company named Wolfson Brands (UK) Limited. That company maintains its headquarters at 12 Payne Street in Glasgow and a US address in South Portland, Maine. The company makes various supplements – from weight loss aids to bodybuilding formulas – for customers worldwide.

Zmyra, on the other hand, is manufactured by a US-based supplement company named Sap Nutra. The company manufactures a range of supplements targeting different health and wellness goals. Other popular supplements include Vyvamind (a cognitive health supplement), Nooceptin (a memory formula), and Xanapril (for anxiety and mood). Sap Nutra manufactures Zmyra and all other supplements in the United States in an FDA-registered, GMP-certified facility.

Final Word: PhenQ vs. Zmyra vs. Ozempic

Although PhenQ, Zmyra, and Ozempic are three popular weight loss products, they work differently.

PhenQ and Zmyra are two popular weight loss supplements. They feature plant extracts, metabolism boosters like caffeine, and other natural ingredients.

Ozempic is an FDA-approved, prescription-only weight management drug that mimics GLP-1 receptors, helping you stay fuller for longer for greater weight loss results.

Ultimately, all three weight loss products have pros and cons. Read our comparison above to determine if PhenQ, Zmyra, or Ozempic may be your choice.

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