Tensions in the eastern Mediterranean have risen over claims and counter claims pitting Turkey against Greece and Cyprus to maritime areas thought to be rich in natural gas.
"Countries in the region need to resolve disagreements including on security and energy resource and maritime issues diplomatically and peacefully," Pompeo said in a fleeting trip to Cyprus on Saturday night, where he met with President Nicos Anastasiades.
"Increased military tensions help no one but adversaries who would like to see division in transatlantic unity," he said.