Israel Air Force jets struck weapon storage facilities used by Hezbollah's Radwan forces in the Qusayr area of Syria, near the Syrian-Lebanese border, the military said on Thursday.
The attack was carried out guided by the Intelligence Directorate.
The military said it was conducting strikes to reduce the transfer of weapons from Iran to Hezbollah via Syria.
The IDF noted that Hezbollah's Munitions Unit recently increased its activities in the border town as part of attempts to set up logistical infrastructure in the area.
The military said that its Syria strike was part of its broader operations in targeting the terror group's Unit 4400, which foresees the transfer of weapons from Iran.
"With the support of the Syrian regime, the Hezbollah terrorist organization endangers the security of Syrian and Lebanese civilians by embedding command centers and forces in civilian areas in both these countries." the IDF said.
Civilians reportedly wounded
Earlier on Thursday, Reuters reported that civilians had been wounded during an alleged Israeli strike in the area, which targeted the city's industrial zone along with residential neighborhoods.
Last week, the IAF targeted Hezbollah infrastructure in the Jousieh border crossing, operated by the Syrian Regime, in the area of northern Beqaa in Lebanon.
Later on Thursday, the military said it had struck Hezbollah terror infrastructure in a strike in the area of Al Housh in southern Lebanon, including that of the Radwan force.
Hezbollah used these areas to carry out terror activities against the State of Israel and the IDF, the military noted, adding that prior to the strike, steps had been taken to prevent harm being done to civilians.
Reuters contributed to this report.