The IDF intercepted a projectile fired from Yemen toward central Israel during the early hours of Tuesday morning, Israel's military said shortly after the incident.
The projectile triggered a wave of sirens throughout central and southern Israel.
There were no reports of casualties from the incident. However, Magen David Adom (MDA) said that paramedics were providing medical care to over 20 people who were injured while seeking shelter during the sirens or who required treatment due to anxiety.
MDA later added that a 60-year-old woman was in severe condition after suffering from a head injury on her way to a shelter. Paramedics evacuated her to Ichilov Hospital in Tel Aviv for treatment.
Houthi official Hezam al-Asad vowed to continue attacks on Israel in an X/Twitter post made approximately 15 minutes after the projectile was launched.
"We will not stop until the aggression against our people in Gaza stops," he wrote.
"[Prime Minister Benjamin] Netanyahu will know that the dreams of the new Middle East are nothing but a curse for him and his imported entity," the post continued.
Rising tensions with the Houthis
This comes after previous Houthi missiles targeted Israel this past week.
On Saturday, sixteen people in Tel Aviv were lightly wounded by glass shards after a Houthi rocket fired from Yemen slammed into Jaffa.
Prior to that, during the early hours of Thursday morning, Yemen fired a missile toward central Israel. Israel Air Force (IAF) fighter jets struck Houthi targets in the capital of Sana'a in Yemen afterward.
Additionally, the US began conducting strikes on Iran-backed Houthi missile storage and command facilities in Yemen's capital, Sana'a, on Saturday night.
This is a developing story.