Air-raid sirens sounded across central Israel at 4 a.m. Thursday morning after the Houthis fired a missile from Yemen.
It was shot down before entering Israeli airspace, the IDF said.
It was the first time in two months the Houthis had targeted the Tel Aviv and Jerusalem areas.
Thirteen people were hurt on their way to protected rooms, and three suffered panic attacks, Magen David Adom (MDA) reported.
US attacks in Yemen
On Wednesday night, the United States struck targets in Sanaa, Yemen’s capital, Beirut-based and Houthi-owned Al-Masirah TV channel reported. It was the fifth consecutive day of US attacks against Yemen.
The Houthis said they had targeted Ben-Gurion Airport with a “Palestine 2” hypersonic ballistic missile.
'The Houthis are paying'
In response, Prime Minister Benjamin Netanyahu said: “The Houthis are already paying [the price] and will continue to pay.”