The figure is up steeply compared with 387 deaths on Thursday and is Lombardy's second highest daily tally so far.
The number of cases in the region, which includes Italy's financial capital Milan, increased by some 2,409 to roughly 37,298 the source said.
On Thursday, 2,543 new cases were registered.
The new cases in Lombardy takes Italy's total number of infections past those recorded in China, where the coronavirus epidemic came to light at the end of last year.
The United States already overtook China's tally on Thursday.
The nationwide tally will be released around 6.00 p.m.