Death toll from the outbreak in China rose to 81 and the virus spread to more than 10 countries including France, Japan and the United States. Some health experts questioned whether China can contain the epidemic.
The pan-European STOXX 600 declined 1.5% by 0808 GMT after hitting a record high in the previous session.
Shares of mining firms slumped 3.1%, dragged down by their exposure to China, and fell the most among all the major European subsectors that were trading in the red.France's CAC lagged regional bourses as luxury goods makers such as LVMH, Hermes and Gucci owner Kering, which are heavily reliant on Chinese demand, fell between 2% and 3%.