The Zahra Center was founded in 2009 by Yahia Gouasmi, a religious figure who has supported the Lebanese Hezbollah terror group.
In 2009, Gouasmi, created an anti-Zionist political party (Parti Antisioniste) that ran in the European elections and included the notorious comedian Dieudonne, who has been widely accused of antisemitism, and far-right polemicist Alain Soral, Le Monde reported.
The French government shut down the Zahra Center in March of last year after it allegedly called for armed jihad, condoning violence by Hezbollah and other terrorist groups.
The center has also been accused of disseminating hate speech, antisemitism and inciting violence.
A judicial source told AFP that the four former leaders of the center were arrested on Tuesday as prosecutors investigated them for "participation in or maintenance of a dissolved association." One of the four has been released for health reasons.
The four are being accused of preaching on site and on social media.
A dawn anti-terror raid by French police on the Zahra Center in October 2018 yielded a cache of illegal firearms.
"The activities of Center Zahra France are under particularly close watch given its leaders' clear support for several terrorist organizations and movements espousing ideas contrary to (French) republican values," read a statement from the prefect's office, at the time.
The Center has ties to Hezbollah and Iranian cells in France, Le Monde reported, and has been a source of "virulent anti-Zionist propaganda."
Reuters contributed to this report.