Israeli army radio said the targets of the attack in Damascus were assets and the headquarters of the Palestinian terrorist group Islamic Jihad.
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Witnesses told Reuters that after Israel struck the Lebanese capital, a blast was heard, and a plume of smoke could be seen.
Safa "was seriously injured and is in critical condition," the sources claimed.
Two people were reportedly killed and nine wounded in the airstrike.
The attack reportedly took place during a meeting between senior Iranian and Hezbollah officials.
In the last two months of the war, the IDF has carried out strikes on almost twenty Hamas command and control centers located in schools.
Sakafi was appointed to head Hezbollah's communications network in 2000 and was closely connected to senior Hezbollah officials.
The strike targeted Hamas commander Zahi Yaser Abd al-Razeq Oufi, who led the Hamas network in Tulkarm, and at least 12 other Hamas, PIJ terrorists were killed.
Initially, the Lebanese military reported that an Israeli drone had struck an army unit working to enable the passage via the Marjeyoun-Hasbaya road of civilians to the town of Koukba.