The coronavirus variant first found in the British region of Kent is a concern because it is mutating and so could undermine the protection given by vaccines against developing COVID-19, the head of the UK's genetic surveillance program said.
She also said the British variant was dominant in the country and was likely "to sweep the world, in all probability."
The coronavirus has killed 2.35 million people and turned normal life upside down for billions, but a few new worrying variants out of thousands have raised fears that vaccines will need to be tweaked and people may require booster shots.
Sharon Peacock, director of the COVID-19 Genomics UK consortium, said vaccines were so far effective against the variants in the United Kingdom, but that mutations could potentially undermine the shots.
"What's concerning about this is that the 1.1.7 variant that we have had circulating for some weeks and months is beginning to mutate again and get new mutations which could affect the way that we handle the virus in terms of immunity and effectiveness of vaccines," Peacock told the BBC.
"It's concerning that the 1.1.7, which is more transmissible, which has swept the country, is now mutating to have this new mutation that could threaten vaccination."
That new mutation, first identified in Bristol in southwest England, has been designated a "Variant of Concern," by the New and Emerging Respiratory Virus Threats Advisory Group.
Britain's chief scientific adviser, Patrick Vallance, said the Bristol variant had one of the same mutations as the South African. "It is not surprising that it has happened and it will happen elsewhere as well," he said on Wednesday.
"In getting that variant it does make it slightly more likely to look different to the immune system so we need to watch out for it, we need to measure it, we need to keep on top of it and need to keep testing the vaccine effects in this situation."
There are so far 21 cases of that variant which has E484K mutation, which occurs on the spike protein of the virus, the same change as has been seen in the South African and Brazilian variants.
"One has to be a realist that this particular mutation has arisen in our kind of communal garden lineage now, at least five times - five separate times. And so this is going to keep popping up," Peacock said.
British people should expect to receive repeated vaccinations against COVID-19 in future to keep pace with mutations of the virus, Prime Minister Boris Johnson said on Wednesday.
There are three major known variants that are worrying scientists: the South African variant, known by scientists as 20I/501Y.V2 or B.1.351; the British variant known as 20I/501Y.V1 or B.1.1.7; and the Brazilian variant known as P.1.
The British variant, which is more infectious but not necessarily more deadly than others, was likely "to sweep the world," Peacock said.
"Once we get on top of (the virus) or it mutates itself out of being virulent - causing disease - then we can stop worrying about it. But I think, looking in the future, we're going to be doing this for years. We're still going to be doing this 10 years down the line, in my view."
The two COVID-19 vaccines developed by Pfizer/BioNTech and AstraZeneca protect against the main British variant.