The missile was intercepted outside Israeli airspace by the IDF 'Arrow' aerial defense system, according to the IDF, causing loud booms and debris to fall.
It is still unclear whether the missile was detected in time and why the Arrow system did not intercept it as planned.
US and Israeli defense leaders met in Washington to enhance technological cooperation and discuss key military systems.
Iran is watching and learning from Israel’s responses. It is likely that Tehran is mobilizing other proxies to increase attacks on Israel.
The working meeting was the first of its kind to be held, the ministry said, adding that it occurred symbolically during the week of Holocaust Remembrance Day.
Since the IDF has one of the world's most advanced integrated air defense systems, if this is an issue for Israel’s military, it is likely to be an issue for other militaries worldwide.
American Christians should speak boldly and ask our leaders to ensure that Israel and the US may continue to collectively enjoy a victory over terror that is strategic and moral.
In the event of an all-out war, the damage Israel will cause to those countries that attack it is tens of times greater than their ability to harm Israel.
The Israeli military earlier said its "Arrow" aerial defense system had intercepted a surface-to-surface missile in the Red Sea area on Friday.
The US defense industry firm Raytheon's exoatmospheric kill vehicle (EKV) was successful in a test to destroy a ballistic missile in space, similar to Israel's Arrow-3.