The deadly blast occurred as thousands of ethnic Armenians fled the breakaway enclave after their fighters were defeated by Azerbaijan in a lightning military operation.
No group has claimed responsibility for the blast, which comes amid a surge in attacks claimed by militant groups in Pakistan.
Iranian authorities in Lorestan in western Iran deny that an earthquake happened and deny rumors of explosions linked to a military center.
According to Channel 12, this is the third recent attempt by criminal organizations to target their crime reporter Shimon Ifergan to stop his reporting.
No casualties have so far been reported and law enforcement said they were investigating the incident.
One of the suspects arrested on Route 431 tied himself to the blast during an investigation by Shin Bet and Border Police.
Following recent use of IEDs in attacks, most notably in a blast near Joseph's Tomb, commandos warned it "will only get worse" in the West Bank.
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