Eight individuals were wounded, with two in serious condition.
At around 2:30 p.m., the Dan District's 102 emergency center received initial calls about a tree caught on fire in southern Tel Aviv.
The attacker was thwarted by security forces and border police officers operating at the checkpoint, the police said.
One murdered victim was a 66-year-old woman Rina Daniv. Her husband, Shimon Daniv, 69, is in serious condition.
According to military guidelines, the residents of several localities in the Northern Galilee were told to stay near shelters following the direct hit.
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The announcement came mere hours before Hezbollah launched a heavy barrage of over 40 rockets and five unmanned aerial vehicles from Lebanon into northern Israel.
Israel's Magen David Adom announced that it had not received any reports of casualties thus far.