Concerns have risen that Iran and Hezbollah could intervene by moving forces and weaponry to assist Assad's regime.
Unlike in Iraq, Yemen, and Lebanon, where Iran relies on proxies, Syria’s regime is directly aligned with Tehran.
The strikes were in response to attacks on US personnel over the past 24 hours, CENTCOM reported.
As drone attacks become more deadly, it’s worth asking what is known about the types of drones that Hezbollah and Iranian proxies are using in their attacks.
US-backed opposition forces attacked pro-government posts in Deir Ezzor, Syria, killing at least 18 fighters, escalating violence.
The Syrian regime wants Ankara to return to the status quo of 2011, before the Syrian revolution and civil war.
The Zaynab shrine has served as a center of pro-Iranian activity since the Syrian civil war began in 2011, and as such has been targeted by other groups.
The IDF carried out artillery strikes against targets in Syria, according to a Damascus correspondent for the Hezbollah-affiliated Al-Mayadeen new site, who reported Monday afternoon.
Syrian state media reported earlier on Wednesday that the country's air defenses had intercepted "hostile targets" over Homs, without giving further details.
One person is reported dead according to a Syrian human rights organization based in the UK.